Direct design of pharmaceutical antisolvent crystallization through concentration control

被引：136

作者：

Zhou, GX

Fujiwara, M

Woo, XY

Rusli, E

Tung, HH

Starbuck, C

Davidson, O

Ge, ZH

Braatz, RD

机构：

[1] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA

[2] Merck & Co Inc, Rahway, NJ 07065 USA

[3] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore

来源：

CRYSTAL GROWTH & DESIGN | 2006年 / 6卷 / 04期

关键词：

D O I：

10.1021/cg0504049

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent advances in in situ measurement technology and automation of batch crystallizers have enabled the development of batch crystallization recipes in which the desired supersaturation profile is followed by feedback control. This paper describes a new approach for following supersaturation setpoints for antisolvent crystallizations that is easy to implement for the tried crystallization. Simulations and application to a proprietary drug compound demonstrate how this combination of automation and in process measurements enables the rapid development of batch crystallization processes in the pharmaceutical industry.

引用

收藏

页码：892 / 898

页数：7

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