Synthesis and identification of conformationally constrained selective MMP inhibitors

被引:34
作者
Freskos, JN [1 ]
McDonald, JJ [1 ]
Mischke, BV [1 ]
Mullins, PB [1 ]
Shieh, HS [1 ]
Stegeman, RA [1 ]
Stevens, AM [1 ]
机构
[1] Searle Discovery Res, Dept Med Chem, St Louis, MO 63198 USA
关键词
D O I
10.1016/S0960-894X(99)00285-1
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
We have discovered a new series of potent conformationally constrained MMP Inhibitors that are selective for MMP-13 over MMP-1. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1757 / 1760
页数:4
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