Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis

被引：77

作者：

Woo, EJ ^{[1
]}

Starks, CM ^{[1
]}

Carney, JR ^{[1
]}

Arslanian, R ^{[1
]}

Cadapan, L ^{[1
]}

Zavala, S ^{[1
]}

Licari, P ^{[1
]}

机构：

[1] Kosan Biosci Inc, Hayward, CA 94545 USA

来源：

JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 02期

关键词：

D O I：

10.7164/antibiotics.55.141

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomyces platensis (strain NRRL 18993), a producer of dorrigocins, was shown to produce migrastatin, a cyclic congener of dorrigocin A previously reported from a different organism. Additionally a new compound isomeric to migrastatin, isomigrastatin, was also isolated and its structure was determined to be a cyclic form of dorrigocin B. Both compounds were fully characterized from MS and NMR data. Product titers of both were improved by the addition of XAD-16 resin to the fermentation medium.

引用

页码：141 / 146

页数：6

共 9 条

[1]

[Anonymous], QUARTERLY, DOI DOI 10.1002/HRDQ.3920070103

[2] DORRIGOCINS - NOVEL ANTIFUNGAL ANTIBIOTICS THAT CHANGE THE MORPHOLOGY OF RAS-TRANSFORMED NIH/3T3 CELLS TO THAT OF NORMAL-CELLS .2. ISOLATION AND ELUCIDATION OF STRUCTURES [J].