A little CIN may cost a lot: revisiting aneuploidy and cancer

被引：45

作者：

Chandhok, Namrata S. ^{[1
]}

Pellman, David ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Childrens Hosp, Dept Pediat Hematol Oncol, Boston, MA 02115 USA

[3] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 01期

基金：

美国国家卫生研究院;

关键词：

MEROTELIC KINETOCHORE ORIENTATION; CHROMOSOME INSTABILITY; MITOTIC CHECKPOINT; ASYMMETRIC DIVISION; GENOME INSTABILITY; YEAST-CELLS; MUTATIONS; TUMORIGENESIS; POLYPLOIDY; EXPRESSION;

D O I：

10.1016/j.gde.2008.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite over 100 years of study, the role of aneuploidy in cancer remains poorly understood. This review highlights the advances in understanding the causes and consequences of aneuploidy. Recent work has illuminated ways in which aneuploidy could have either tumor-promoting or tumor-suppressing effects, similar to what is known for other forms of genetic instability such as telomere attrition [Maser RS, DePinho RA: Connecting chromosomes, crisis, and cancer. Science 2002, 297:565-569]. We explore the possibility that aneuploidy could be just another type of 'mutation', with potential beneficial and deleterious effects, depending on the chromosomes involved and the specific selective pressures the cells experience. We also discuss the potential therapeutic implications of changes in physiology associated with aneuploidy.

引用

页码：74 / 81

页数：8

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