A little CIN may cost a lot: revisiting aneuploidy and cancer

被引：45

作者：

Chandhok, Namrata S. ^{[1
]}

Pellman, David ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Childrens Hosp, Dept Pediat Hematol Oncol, Boston, MA 02115 USA

[3] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 01期

基金：

美国国家卫生研究院;

关键词：

MEROTELIC KINETOCHORE ORIENTATION; CHROMOSOME INSTABILITY; MITOTIC CHECKPOINT; ASYMMETRIC DIVISION; GENOME INSTABILITY; YEAST-CELLS; MUTATIONS; TUMORIGENESIS; POLYPLOIDY; EXPRESSION;

D O I：

10.1016/j.gde.2008.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite over 100 years of study, the role of aneuploidy in cancer remains poorly understood. This review highlights the advances in understanding the causes and consequences of aneuploidy. Recent work has illuminated ways in which aneuploidy could have either tumor-promoting or tumor-suppressing effects, similar to what is known for other forms of genetic instability such as telomere attrition [Maser RS, DePinho RA: Connecting chromosomes, crisis, and cancer. Science 2002, 297:565-569]. We explore the possibility that aneuploidy could be just another type of 'mutation', with potential beneficial and deleterious effects, depending on the chromosomes involved and the specific selective pressures the cells experience. We also discuss the potential therapeutic implications of changes in physiology associated with aneuploidy.

引用

页码：74 / 81

页数：8

共 65 条

[31] When 2+2=5: The origins and fates of aneuploid and tetraploid cells [J].

King, Randall W. .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2008, 1786 (01) :4-14

[32] Aurora B is enriched at merotelic attachment sites, where it regulates MCAK [J].

Knowlton, Anne Lide ;

Lan, Weijie ;

Stukenberg, P. Todd .

CURRENT BIOLOGY, 2006, 16 (17) :1705-1710

[33] Maintenance of genome stability in Saccharomyces cerevisiae [J].

Kolodner, RD ;

Putnam, CD ;

Myung, K .

SCIENCE, 2002, 297 (5581) :552-557

[34] Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes [J].

Kwon, Mijung ;

Godinho, Susana A. ;

Chandhok, Namrata S. ;

Ganem, Neil J. ;

Azioune, Ammar ;

Thery, Manuel ;

Pellman, David .

GENES & DEVELOPMENT, 2008, 22 (16) :2189-2203

[35] Genetic instability in colorectal cancers [J].

Lengauer, C ;

Kinzler, KW ;

Vogelstein, B .

NATURE, 1997, 386 (6625) :623-627

[36] Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome [J].

Matsuura, S ;

Matsumoto, Y ;

Morishima, K ;

Izumi, H ;

Matsumoto, H ;

Ito, E ;

Tsutsui, K ;

Kobayashi, J ;

Tauchi, H ;

Kajiwara, Y ;

Hama, S ;

Kurisu, K ;

Tahara, H ;

Oshimura, M ;

Komatsu, K ;

Ikeuchi, T ;

Kajii, T .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2006, 140A (04) :358-367

[37] HIGH-LEVELS OF CHROMOSOME INSTABILITY IN POLYPLOIDS OF SACCHAROMYCES-CEREVISIAE [J].

MAYER, VW ;

AGUILERA, A .

MUTATION RESEARCH, 1990, 231 (02) :177-186

[38] Can chromosomal instability initiate tumorigenesis? [J].

Michor, F ;

Iwasa, Y ;

Vogelstein, B ;

Lengauer, C ;

Nowak, MA .

SEMINARS IN CANCER BIOLOGY, 2005, 15 (01) :43-49

[39] The spindle-assembly checkpoint in space and time [J].

Musacchio, Andrea ;

Salmon, Edward D. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (05) :379-393

[40] Centrosome aberrations: Cause or consequence of cancer progression? [J].

Nigg, EA .

NATURE REVIEWS CANCER, 2002, 2 (11) :815-825

← 1 2 3 4 5 6 7 →