A role for NT-3 in the hyperinnervation of neonatally wounded skin

被引：32

作者：

Beggs, Simon ^{[1
,2
]}

Alvares, Debie ^{[3
]}

Moss, Andrew ^{[3
]}

Currie, Gillian ^{[2
]}

Middleton, Jacqueta ^{[3
]}

Salter, Michael W. ^{[1
]}

Fitzgerald, Maria ^{[3
]}

机构：

[1] Hosp Sick Children, Programme Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Fac Dent, Toronto, ON, Canada

[3] UCL, Dept Neurosci Physiol & Pharmacol, London, England

来源：

PAIN | 2012年 / 153卷 / 10期

基金：

英国医学研究理事会; 加拿大健康研究院;

关键词：

Neurotrophin; Pain; Sprouting; Sensory neuron; Cutaneous; NERVE GROWTH-FACTOR; SENSORY NEURONS; IN-VITRO; CUTANEOUS MECHANORECEPTORS; PAIN MANAGEMENT; HAIR FOLLICLE; NEUROTROPHIN-3; INNERVATION; EXPRESSION; RECEPTORS;

D O I：

10.1016/j.pain.2012.07.012

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Neurotrophin-3 (NT-3) is a target-derived neurotrophic factor that regulates sensory neuronal survival and growth. Here we report that NT-3 plays a critical permissive role in cutaneous sensory nerve sprouting that contributes to pain and sensitivity following skin wounding in young animals. Sensory terminal sprouting in neonatally wounded dermis and epidermis is accompanied by increased NT-3 transcription, NT-3 protein levels, and NT-3 protein release 3-7 days post skin injury in newborn rats and mice. Functional blockade of NT-3 activity with specific antibodies greatly reduces sensory neurite outgrowth induced by wounded skin, but not by naive skin, in dorsal root ganglion/skin co-cultures. The requirement for NT-3 for sensory terminal sprouting in vivo is confirmed by the absence of wound-induced hyperinnervation in heterozygous transgenic mice (NT-3(+/) lacZ). We conclude that upregulation of NT-3 in neonatally wounded skin is a critical factor mediating the sensory nerve sprouting that underlies hypersensitivity and pain following skin injury. (C) 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

引用

页码：2133 / 2139

页数：7

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