The therapeutic efficacy of CdTe and CdSe quantum dots for photothermal cancer therapy

被引：143

作者：

Chu, Maoquan ^{[1
]}

Pan, Xiaojing ^{[2
]}

Zhang, Ding ^{[1
]}

Wu, Qiang ^{[1
]}

Peng, Jinliang ^{[3
]}

Hai, Wangxi ^{[3
]}

机构：

[1] Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China

[2] Tongji Univ, Sch Med, Shanghai 200092, Peoples R China

[3] Shanghai Jiao Tong Univ, Med X Inst, Shanghai 200240, Peoples R China

来源：

BIOMATERIALS | 2012年 / 33卷 / 29期

基金：

中国国家自然科学基金;

关键词：

Fluorescent quantum dots; CdTe; CdSe; Melanoma; Photothermal therapy; NANOPARTICLES; NANOCRYSTALS; CELLS;

D O I：

10.1016/j.biomaterials.2012.06.062

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Fluorescent quantum dots (QDs) used for biomedical imaging and diagnostics have attracted considerable attention over the past decade. Here, we report our finding regarding the therapeutic efficacy of the popularly used red/brown, brown or close to black CdTe and CdSe QDs. Upon 671-nm laser irradiation, these QDs can rapidly convert light energy into heat, both in vitro and in vivo. In the present study, the growth of mouse melanoma tumors injected with CdTe(710) QDs coated with a silica shell (SiO2) was significantly inhibited after laser irradiation, with eventual disappearance of the tumor. In contrast, tumors injected with the silica-coated QDs without subsequent irradiation continued to grow over time. They had a growth rate close to that of tumors injected with SiO2 or phosphate-buffered saline, with or without laser irradiation. In conclusion, our data suggest that the popularly used CdTe and CdSe QDs have great potential in the treatment of cancer using photothermal therapy. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：7071 / 7083

页数：13

共 29 条

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