Cholestane steroid glycosides from the rhizomes of Dioscorea villosa (wild yam)

被引：25

作者：

Ali, Zulfiqar ^{[1
]}

Smillie, Troy J. ^{[1
]}

Khan, Ikhlas A. ^{[1
,2
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Dept Pharmacognosy, University, MS 38677 USA

来源：

CARBOHYDRATE RESEARCH | 2013年 / 370卷

关键词：

Dioscorea villosa; Dioscoreaceae; Wild yam; Cholestane steroid; Dioscoreavilloside A; Dioscoreavilloside B; WALL VAR. ORBICULATA; ANTIFUNGAL ACTIVITY; SAPONINS;

D O I：

10.1016/j.carres.2012.12.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Phytochemical investigation of the MeOH extract of Dioscorea villosa rhizomes resulted in the isolation of two new bidesmosidic cholestane steroid glycosides, dioscoreavillosides A and B (1 and 2). In addition, the extract yielded 12 previously known furostan and spirostan steroid glycosides (3-14), along with diosgenin (15). Compounds 3-7, 9, 14, and 15 were isolated for the first time from D. villosa. The structures of the isolated compounds were determined using spectroscopic and chemical methods including 1D and 2D NMR. The antimicrobial action of most of these compounds was tested against five fungal and five bacterial strains. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：86 / 91

页数：6

共 27 条

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