Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease

被引：29

作者：

Tracy, S

Chapman, NM

Romero, J

Ramsingh, AI

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL,OMAHA,NE 68198

[2] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,ALBANY,NY 12201

[3] CREIGHTON UNIV UNIV NEBRASKA,COMBINED DIV PEDIAT INFECT DIS,OMAHA,NE 68178

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 05期

关键词：

D O I：

10.1016/0966-842X(96)10026-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coxsackieviruses B (CVBs) are etiological agents of human inflammatory myocardial disease. The genetics of the coxsackieviral virulence phenotype in mice are now beginning to be understood with the availability of infectious cDNA copies of CVB genomes. Investigations to date with CVB3 and CVB4 have shown that sites within a non-translated region and in the capsid proteins can affect the virulence phenotype. The relative importance of these sites to expression of the phenotype remains unclear.

引用

页码：175 / 179

页数：5

共 38 条

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