Reaching a genetic and molecular understanding of skeletal development

被引:1217
作者
Karsenty, G [1 ]
Wagner, EF
机构
[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[2] Res Inst Mol Pathol, IMP, A-1030 Vienna, Austria
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S1534-5807(02)00157-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes and presents, in several cases, the genetic cascade leading to cell differentiation.
引用
收藏
页码:389 / 406
页数:18
相关论文
共 150 条
[91]  
OHBAYASHI N, 2002, IN PRESS GENES DEV
[92]  
Ornitz DM, 2001, GENOME BIOL, V2
[93]   Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development [J].
Otto, F ;
Thornell, AP ;
Crompton, T ;
Denzel, A ;
Gilmour, KC ;
Rosewell, IR ;
Stamp, GWH ;
Beddington, RSP ;
Mundlos, S ;
Olsen, BR ;
Selby, PB ;
Owen, MJ .
CELL, 1997, 89 (05) :765-771
[94]  
Owens JM, 1999, J CELL PHYSIOL, V179, P170, DOI 10.1002/(SICI)1097-4652(199905)179:2<170::AID-JCP7>3.0.CO
[95]  
2-K
[96]   Mutations in CDMP1 cause autosomal dominant brachydactyly type C [J].
Polinkovsky, A ;
Robin, NH ;
Thomas, JT ;
Irons, M ;
Lynn, A ;
Goodman, FR ;
Reardon, W ;
Kant, SG ;
Brunner, HG ;
vanderBurgt, I ;
Chitayat, D ;
McGaughran, J ;
Donnai, D ;
Luyten, FP ;
Warman, ML .
NATURE GENETICS, 1997, 17 (01) :18-19
[97]  
Poole A. R., 1991, CARTILAGE MOL ASPECT, P179
[98]  
Reddi A. Hari, 1997, Cytokine and Growth Factor Reviews, V8, P11, DOI 10.1016/S1359-6101(96)00049-4
[99]   Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice [J].
Reimold, AM ;
Grusby, MJ ;
Kosaras, B ;
Fries, JWU ;
Mori, R ;
Maniwa, S ;
Clauss, IM ;
Collins, T ;
Sidman, RL ;
Glimcher, MJ ;
Glimcher, LH .
NATURE, 1996, 379 (6562) :262-265
[100]   ATRIAL-NATRIURETIC-FACTOR AND RELATED PEPTIDE-HORMONES [J].
ROSENZWEIG, A ;
SEIDMAN, CE .
ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 :229-255