Antigen receptor 'capacity' and the sensitivity of self-tolerance

It seems unlikely that the immune system can actively avoid the generation of self-reactive cells in the primary, pre-selected repertoire. On the contrary, by generating a very high proportion of self-reactive B cells in its primary repertoire, the immune system may be pursuing the most efficient strategy for building a repertoire capable of optimally recognizing nonself, as discussed here by David Nemazee.