MICE LACKING TDT - MATURE ANIMALS WITH AN IMMATURE LYMPHOCYTE REPERTOIRE

被引：364

作者：

GILFILLAN, S ^{[1
]}

DIERICH, A ^{[1
]}

LEMEUR, M ^{[1
]}

BENOIST, C ^{[1
]}

MATHIS, D ^{[1
]}

机构：

[1] INST CHIM BIOL,INSERM,U184,UNITE BIOL MOLEC,F-67085 STRASBOURG,FRANCE

来源：

SCIENCE | 1993年 / 261卷 / 5125期

关键词：

D O I：

10.1126/science.8356452

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In adult animals, template-independent (or N) nucleotides are frequently added during the rearrangement of variable (V), diversity (D), and joining (J) segments of lymphocyte receptor genes, greatly enhancing junctional diversity. Receptor genes from adult mice carrying a mutation in the terminal deoxynucleotidyl transferase (TdT) gene have few N nucleotides, providing proof that this enzyme is essential for creating diversity. Unlike those from normal adults, receptor genes from adult mutant mice show extensive evidence of homology-directed recombination, suggesting that TdT blocks this process. Thus, switch-on of the TdT gene during the first week after birth provokes an even greater expansion of lymphocyte receptor diversity than had previously been thought.

引用

页码：1175 / 1178

页数：4

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