Syngeneic stem cell transplantation for HIV-related lymphoma

被引：24

作者：

Campbell, P ^{[1
]}

Iland, H ^{[1
]}

Gibson, J ^{[1
]}

Joshua, D ^{[1
]}

机构：

[1] Royal Prince Alfred Hosp, Kanematsu Labs, Inst Haematol, Camperdown, NSW 2050, Australia

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 105卷 / 03期

关键词：

HIV; lymphoma; syngeneic; transplant; antiretrovirals;

D O I：

10.1046/j.1365-2141.1999.01422.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The treatment of human immunodeficiency virus (HIV)-related lymphoma is beset by a number of therapeutic limitations. High-dose chemotherapy followed by peripheral blood stem cell transplantation (PBSCT) for relapsed disease is one option, but may be compromised by unacceptable treatment-related morbidity and mortality. We describe an HIV-positive male with relapsed immunoblastic non-Hodgkin's lymphoma (NHL) who successfully received salvage chemotherapy followed by a syngeneic PBSCT from his HIV-negative (hepatitis C positive) brother. At 15 months post transplant he remains in complete remission with low-level HIV viral load, an improved CD4 lymphocyte count and absent anti-hepatitis C antibodies. We believe selected patients with relapsed HIV-related NHL should be considered for high-dose therapy.

引用

页码：795 / 798

页数：4