Classification of PDZ domains

被引：106

作者：

Bezprozvanny, I ^{[1
]}

Maximov, A ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Physiol, Dallas, TX 75235 USA

来源：

FEBS LETTERS | 2001年 / 509卷 / 03期

基金：

美国国家卫生研究院;

关键词：

PDZ domain; primary sequence analysis; sequence database search; Mint1; INADL; PAR6;

D O I：

10.1016/S0014-5793(01)03214-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A diverse family of PDZ domains has been identified, but the rules that govern their ligand specificity are not clear. Here we propose a novel classification of PDZ domains based on the nature of amino acids in the two critical positions in the PDZ domain fold. Using these principles, we classified PDZ domains present in the SMART database. Using yeast two-hybrid, in vitro pull-down and plasmon surface resonance assays, we demonstrated that in agreement with their position in the proposed classification the Mint1-1, hINADL-5, and PAR6 PDZ domains display similar dual ligand specificity. The proposed classification helps to organize PDZ domain containing proteins. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：457 / 462

页数：6

共 34 条

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