Hemispheric asymmetry reduction in older adults: The HAROLD model

被引：1745

作者：

Cabeza, R ^{[1
]}

机构：

[1] Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA

来源：

PSYCHOLOGY AND AGING | 2002年 / 17卷 / 01期

关键词：

D O I：

10.1037//0882-7974.17.1.85

中图分类号：

R4 [临床医学]; R592 [老年病学];

学科分类号：

1002 ; 100203 ; 100602 ;

摘要：

A model of the effects of aging on brain activity during cognitive performance is introduced. The model is called HAROLD (hemispheric asymmetry reduction in older adults), and it states that, under similar circumstances, prefrontal activity during cognitive performances tends to be less lateralized in older adults than in younger adults. The model is supported by functional neuroimaging and other evidence in the domains of episodic memory, semantic memory, working memory, perception, and inhibitory control. Age-related hemispheric asymmetry reductions may have a compensatory function or they may reflect a dedifferentiation process. They may have a cognitive or neural origin, and they may reflect regional or network mechanisms. The HAROLD model is a cognitive neuroscience model that integrates ideas and findings from psychology and neuroscience of aging.

引用

页码：85 / 100

页数：16

共 125 条

[11] The relation of planum temporale asymmetry and morphology of the corpus callosum to handedness, gender, and dyslexia: A review of the evidence [J].