Gold(I)-catalyzed intramolecular hydroamination of alkenyl carbamates

被引：209

作者：

Han, XQ ^{[1
]}

Widenhoefer, RA ^{[1
]}

机构：

[1] Duke Univ, PM Gross Chem Lab, Durham, NC 27708 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 11期

关键词：

alkenes; amines; gold; homogeneous catalysis; hydroamination;

D O I：

10.1002/anie.200600052

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Gold for rings: Reaction of alkenyl carbamates such as 1 in the presence of [Au{P(tBu)2(o-biphenyl)}]Cl and AgOTf led to nitrogen heterocycles (e.g. 2). This AuI-catalyzed intramolecular hydroamination tolerates a range of labile carbamates and substitution patterns and can be applied to the synthesis of bicyclic carbamates and protected piperidines. Cbz = benzyloxycarbonyl. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1747 / 1749

页数：3

共 37 条

[1] Palladium-catalyzed ring-forming aminoacetoxylation of alkenes [J].