Novel pharmacotherapeutic targets for the management of drug addiction

被引：30

作者：

Heidbreder, C ^{[1
]}

机构：

[1] GlaxoSmithKline, Dept Neuropsychopharmacol, Ctr Excellence Drug Discovery Psychiat, I-37135 Verona, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 526卷 / 1-3期

关键词：

alcohol; cocaine; drug addiction; nicotine; opiates; pharmacotherapy;

D O I：

10.1016/j.ejphar.2005.09.038

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite individual variation in the liability to the abuse of psychoactive substances, there is substantial commonality shared by drugs of abuse. The knowledge of these common mechanisms together with the continued elucidation of the neurobiological underpinnings of withdrawal symptoms, drug intake, craving, relapse, and co-morbid psychiatric associations are critically important for the development of new therapeutic strategies. The present review will focus on recent advances in the development of innovative pharmacotherapeutic agents, which should promote higher efficacy (abstinence, prevention of relapse, long-term recovery) and patient compliance, as well as improved safety profiles. (c) 2005 Elsevier B.V. All rights reserved.

引用

收藏

页码：101 / 112

页数：12

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