Viral encoded cyclins

被引：20

作者：

Cannell, E ^{[1
]}

Mittnacht, S ^{[1
]}

机构：

[1] Inst Canc Res, Dept Cell & Mol Biol, London SW3 6JB, England

来源：

SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 03期

关键词：

HHV-8; KSHV; HVS; MHV-68; cyclin; virus; cell cycle;

D O I：

10.1006/scbi.1999.0090

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cyclins are known effecters of cellular proliferation. While originally considered as the product of cellular genes, it is now clear that representatives of this class of proteins can be encoded by certain viruses. One of these viruses is HHV-8, a gamma herpesvirus implicated as a causative agent of Kaposi's Sarcoma and lymphomas in humans. The significance of the virally encoded cyclin. proteins in viral propagation is as yet unclear. However, the fact that deregulation of cellular cyclin expression is a known event in tumour development suggests that the virally encoded cyclins could be part of a mechanism utilised by these viruses to induce tumour formation.

引用

页码：221 / 229

页数：9

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