Beyond vancomycin: New therapies to meet the challenge of glycopeptide resistance

被引：31

作者：

Nicas, TI ^{[1
]}

Zeckel, ML ^{[1
]}

Braun, DK ^{[1
]}

机构：

[1] ELI LILLY & CO, LILLY RES LABS, INDIANAPOLIS, IN 46285 USA

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 06期

关键词：

D O I：

10.1016/S0966-842X(97)01051-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The incidence of infections caused by resistant Gram-positive pathogens is increasing, while emergence of vancomycin resistance is reducing the number of therapeutic options. New agents are being rapidly evaluated as candidates to replace vancomycin; some of the most promising include semisynthetic glycopeptides, quinupristin-dalfopristin, oxazolidinones and everninomycins. Alternative strategies, including immunization and therapeutic vaccines, may also have a role.

引用

页码：240 / 249

页数：10

共 75 条

[1] Inhibition of peptidoglycan biosynthesis in vancomycin-susceptible and -resistant bacteria by a semisynthetic glycopeptide antibiotic [J].

Allen, NE ;

Hobbes, JN ;

Nicas, TI .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (10) :2356-2362

[2]

[Anonymous], 1995, INFECT CONT HOSP EP, V16, P105

[3] PREDOMINANCE OF 2 NEWLY DESCRIBED CAPSULAR POLYSACCHARIDE TYPES AMONG CLINICAL ISOLATES OF STAPHYLOCOCCUS-AUREUS [J].

ARBEIT, RD ;

KARAKAWA, WW ;

VANN, WF ;

ROBBINS, JB .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1984, 2 (02) :85-91

[4] Mechanisms of glycopeptide resistance in enterococci [J].

Arthur, M ;

Reynolds, PE ;

Depardieu, F ;

Evers, S ;

DutkaMalen, S ;

Quintiliani, R ;

Courvalin, P .

JOURNAL OF INFECTION, 1996, 32 (01) :11-16

[5] Glycopeptide resistance in enterococci [J].

Arthur, M ;

Reynolds, P ;

Courvalin, P .

TRENDS IN MICROBIOLOGY, 1996, 4 (10) :401-407

[6] GENETICS AND MECHANISMS OF GLYCOPEPTIDE RESISTANCE IN ENTEROCOCCI [J].

ARTHUR, M ;

COURVALIN, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) :1563-1571

[7] FARM-ANIMALS AS A PUTATIVE RESERVOIR FOR VANCOMYCIN-RESISTANT ENTEROCOCCAL INFECTION IN MAN [J].

BATES, J ;

JORDENS, JZ ;

GRIFFITHS, DT .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (04) :507-514

[8] DIMERIZATION AND MEMBRANE ANCHORS IN EXTRACELLULAR TARGETING OF VANCOMYCIN GROUP ANTIBIOTICS [J].

BEAUREGARD, DA ;

WILLIAMS, DH ;

GWYNN, MN ;

KNOWLES, DJC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (03) :781-785

[9] Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection [J].

Bergeron, J ;

Ammirati, M ;

Danley, D ;

James, L ;

Norcia, M ;

Retsema, J ;

Strick, CA ;

Su, WG ;

Sutcliffe, J ;

Wondrack, L .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (09) :2226-2228

[10]

BIAVASCO F, 1996, EUR J CLIN MICROBIOL, V54, P15

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