Beyond vancomycin: New therapies to meet the challenge of glycopeptide resistance

被引：31

作者：

Nicas, TI ^{[1
]}

Zeckel, ML ^{[1
]}

Braun, DK ^{[1
]}

机构：

[1] ELI LILLY & CO, LILLY RES LABS, INDIANAPOLIS, IN 46285 USA

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 06期

关键词：

D O I：

10.1016/S0966-842X(97)01051-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The incidence of infections caused by resistant Gram-positive pathogens is increasing, while emergence of vancomycin resistance is reducing the number of therapeutic options. New agents are being rapidly evaluated as candidates to replace vancomycin; some of the most promising include semisynthetic glycopeptides, quinupristin-dalfopristin, oxazolidinones and everninomycins. Alternative strategies, including immunization and therapeutic vaccines, may also have a role.

引用

页码：240 / 249

页数：10

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