Quinupristin-dalfopristin

被引:39
作者
Bryson, HM
Spencer, CM
机构
[1] Adis International Limited, Mairangi Bay, Auckland 10
关键词
D O I
10.2165/00003495-199652030-00006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Quinupristin-dalfopristin (RP 59500) is an injectable streptogramin antibiotic. It possesses a wide spectrum of activity against Gram-positive bacteria including methicillin-resistant staphylococci, glycopeptide-resistant Enterococcus faecium and penicillin-resistant pneumococci. Quinupristin-dalfopristin has activity against some anaerobes and selected Gram-negative pathogens. Quinupristin-dalfopristin, by way synergism of between its 2 components, is unaffected by most forms of bacterial resistance. Rare forms of macrolide-lincosamide-streptogramin group B resistance may affect its activity; however, at present the incidence of strains with this type of resistance remains low. Quinupristin-dalfopristin is bactericidal against streptococci and staphylococci but has weak or no bactericidal activity against enterococci. In a compassionate use programme, 67% of 95 evaluable patients with vancomycin-resistant Gram-positive infections or intolerant of vancomycin showed improvement with eradication of infection.
引用
收藏
页码:406 / 415
页数:10
相关论文
共 61 条
[1]  
ALCAIDE F, 1995, 35 INT C ANT AG CHEM, P94
[2]   INVITRO ANTISTAPHYLOCOCCAL ACTIVITY AND TESTING OF RP-59500, A NEW STREPTOGRAMIN, BY 2 METHODS [J].
ALDRIDGE, KE ;
SCHIRO, DD ;
VARNER, LM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (04) :854-855
[3]   SEQUENCE OF A STAPHYLOCOCCAL PLASMID GENE, VGA, ENCODING A PUTATIVE ATP-BINDING PROTEIN INVOLVED IN RESISTANCE TO VIRGINIAMYCIN A-LIKE ANTIBIOTICS [J].
ALLIGNET, J ;
LONCLE, V ;
ELSOLH, N .
GENE, 1992, 117 (01) :45-51
[4]   THE IN-VITRO ACTIVITY OF A NEW SEMISYNTHETIC STREPTOGRAMIN COMPOUND, RP-59500, AGAINST STAPHYLOCOCCI AND RESPIRATORY PATHOGENS [J].
ANDREWS, JM ;
WISE, R .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 33 (04) :849-853
[5]   SUSCEPTIBILITY OF 539 GRAM-POSITIVE AND GRAM-NEGATIVE ANAEROBES TO NEW AGENTS, INCLUDING RP59500, BIAPENEM, TROSPECTOMYCIN AND PIPERACILLIN TAZOBACTAM [J].
APPELBAUM, PC ;
SPANGLER, SK ;
JACOBS, MR .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 32 (02) :223-231
[6]   RP-59500, A NEW STREPTOGRAMIN HIGHLY-ACTIVE AGAINST RECENT ISOLATES OF NORTH-AMERICAN STAPHYLOCOCCI [J].
ARCHER, GL ;
AUGER, P ;
DOERN, GV ;
FERRARO, MJ ;
FUCHS, PC ;
JORGENSEN, JH ;
LOW, DE ;
MURRAY, PR ;
RELLER, LB ;
STRATTON, CW ;
WENNERSTEN, CB ;
MOELLERING, RC .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1993, 16 (03) :223-226
[7]  
BAQUERO F, 1993, 33 INT C ANT AG CHEM, P204
[8]   IN-VITRO ACTIVITIES OF A STREPTOGRAMIN (RP59500), 3 MACROLIDES, AND AN AZALIDE AGAINST 4 RESPIRATORY-TRACT PATHOGENS [J].
BARRY, AL ;
FUCHS, PC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (01) :238-240
[9]  
BERGERON MG, 1995, CAN J INFECT DIS SC, P232
[10]   PHARMACOKINETICS AND SUCTION BLISTER FLUID PENETRATION OF A SEMISYNTHETIC INJECTABLE STREPTOGRAMIN RP-59500 (RP-57669 RP-54476) [J].
BERNARD, E ;
BENSOUSSAN, M ;
BENSOUSSAN, F ;
ETIENNE, S ;
CAZENAVE, I ;
CARSENTIETESSE, E ;
LEROUX, Y ;
MONTAY, G ;
DELLAMONICA, P .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1994, 13 (09) :768-771