Pregnancy and birth rates after oocyte donation

被引:82
作者
Remohi, J
Gartner, B
Gallardo, E
Yalil, S
Simon, C
Pellicer, A
机构
[1] INST VALENCIANO INFERTIL,VALENCIA 46020,SPAIN
[2] UNIV VALENCIA,SCH MED,DEPT PEDIAT OBSTET & GYNECOL,VALENCIA,SPAIN
关键词
oocyte donation; pregnancy; live birth; reproductive outcome;
D O I
10.1016/S0015-0282(97)81372-6
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine accumulated conception and live birth rates in ovum donation. Design: Retrospective study from a computer database. Pregnancies with one gestational sac observed by ultrasound have been included as conceptional cycles and pregnancies that resulted in one live child were recorded for the analysis of the live birth rates. Life table analysis was applied. Setting: Oocyte donation program at the Institute Valenciano de Infertilidad. Patient(s): Three hundred ninety-seven recipients undergoing a total of 627 ETs were analyzed. Intervention(s): Ovarian stimulation and ovum pick-up in donors. Uterine ET in recipients after appropriate exogenous steroid replacement. Main Outcome Measurement(s): Accumulated and estimated (95% confidence intervals [CI]) conception and live birth rates in the oocyte donation program as well as considering age and cause of infertility of the recipients. Result(s): Pregnancy rate after one cycle was 53.4% (CI 50.9% to 55.9%), with a delivery rate of 42.6% (CI 40.1% to 45.1%). Accumulated pregnancy rate increased up to 94.8% (CI 90.6% to 99.0%) after four transfers. Similarly, live birth rates reached 88.7% (CI 88.1% to 89.3%) after four attempts of ET by ovum donation. Cycle fecundity rates were maintained at approximately 50% after each attempt. Implantation rate was 18.3% (430/2,340 replaced embryos). Age and cause of entering the program did not influence the overall results of ovum donation. Conclusion(s): Oocyte donation is a successful treatment modality for infertile couples that offers even higher success rates than natural conception. No difference in cumulative pregnancy rate was observed regardless of recipient age, indication for oocyte donation, or number of cycles attempted. (C) 1997 by American Society for Reproductive Medicine.
引用
收藏
页码:717 / 723
页数:7
相关论文
共 24 条
[11]   THE EVOLUTION AND OUTCOME OF PREGNANCIES FROM OOCYTE DONATION [J].
PADOS, G ;
CAMUS, M ;
VANSTEIRTEGHEM, A ;
BONDUELLE, M ;
DEVROEY, P .
HUMAN REPRODUCTION, 1994, 9 (03) :538-542
[12]   OVARIAN RESPONSE AND OUTCOME OF INVITRO FERTILIZATION IN PATIENTS TREATED WITH GONADOTROPIN-RELEASING HORMONE ANALOGS IN DIFFERENT PHASES OF THE MENSTRUAL-CYCLE [J].
PELLICER, A ;
SIMON, C ;
MIRO, F ;
CASTELLVI, RM ;
RUIZ, A ;
RUIZ, M ;
PEREZ, M ;
BONILLAMUSOLES, F .
HUMAN REPRODUCTION, 1989, 4 (03) :285-289
[13]   Lower implantation rates in high responders: Evidence for an altered endocrine milieu during the preimplantation period [J].
Pellicer, A ;
Valbuena, D ;
Cano, F ;
Remohi, J ;
Simon, C .
FERTILITY AND STERILITY, 1996, 65 (06) :1190-1195
[14]   THE USE OF GONADOTROPIN-RELEASING-HORMONE ANALOGS IN WOMEN RECEIVING OOCYTE DONATION DOES NOT AFFECT IMPLANTATION RATES [J].
REMOHI, J ;
GUTIERREZ, A ;
VIDAL, A ;
TARIN, JJ ;
PELLICER, A .
HUMAN REPRODUCTION, 1994, 9 (09) :1761-1764
[15]  
REMOHI J, 1993, FERTIL STERIL, V59, P1208
[16]  
REMOHI J, 1995, HUM REPROD, V6, P1387
[17]  
ROSENWAKS Z, 1987, FERTIL STERIL, V47, P895
[18]   PREGNANCY AFTER AGE 50 - APPLICATION OF OOCYTE DONATION TO WOMEN AFTER NATURAL MENOPAUSE [J].
SAUER, MV ;
PAULSON, RJ ;
LOBO, RA .
LANCET, 1993, 341 (8841) :321-323
[19]   300 CYCLES OF OOCYTE DONATION AT THE UNIVERSITY-OF-SOUTHERN-CALIFORNIA - ASSESSING THE EFFECT OF AGE AND INFERTILITY DIAGNOSIS ON PREGNANCY AND IMPLANTATION RATES [J].
SAUER, MV ;
PAULSON, RJ ;
ARY, BA ;
LOBO, RA .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1994, 11 (02) :92-96
[20]   OUTCOME OF PATIENTS WITH ENDOMETRIOSIS IN ASSISTED REPRODUCTION - RESULTS FROM IN-VITRO FERTILIZATION AND OOCYTE DONATION [J].
SIMON, C ;
GUTIERREZ, A ;
VIDAL, A ;
DELOSSANTOS, MJ ;
TARIN, JJ ;
REMOHI, J ;
PELLICER, A .
HUMAN REPRODUCTION, 1994, 9 (04) :725-729