Lack of association between the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in HIV-1-infected South African children

被引：65

作者：

McNally, Lisa M.

Jeena, Prakash M.

Gajee, Kavitha

Sturm, A. Willem

Tomkins, Andrew M.

Coovadia, Hoosen M.

Goldblatt, David

机构：

[1] UCL, Ctr Int Child Hlth, London, England

[2] UCL, Immunobiol Unit, Inst Child Hlth, London, England

[3] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Paediat & Child Hlth, Durban, South Africa

[4] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Med Microbiol, Durban, South Africa

[5] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Doris Duke Med Res Inst, Durban, South Africa

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 194卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1086/505076

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in 355 children hospitalized with severe pneumonia. Of the children, 239 (67.3%) were human immunodeficiency virus (HIV)-1 positive; 169 (47.6%) carried S. pneumoniae, 91 (25.6%) carried S. aureus, and 33 (9.3%) carried both. S. pneumoniae carriage was not related to HIV-1 status. The HIV-1-positive children had a significantly higher rate of S. aureus carriage than did the HIV-1-negative children (31.4% vs. 13.8%; P <.001). The rate of S. aureus carriage in the HIV-1-negative S. pneumoniae carriers was significantly lower than that in the noncarriers (5.5% vs. 21.3%; P=.013), but the rate of S. aureus carriage in the HIV-1-positive S. pneumoniae carriers was not significantly lower than that in the noncarriers (26.3% vs. 36.0%;). We did not find a negative association between S. pneumoniae and S. aureus carriage in HIV-1-positive hospitalized children with severe pneumonia.

引用

页码：385 / 390

页数：6

共 14 条

[11] Prevalence of methicillin-resistant and methicillin-susceptible Staphylococcus aureus in the community [J].