Functionalized DNA Nanostructures

被引：332

作者：

Wilner, Ofer I. ^{[1
]}

Willner, Itamar ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel

来源：

CHEMICAL REVIEWS | 2012年 / 112卷 / 04期

基金：

以色列科学基金会;

关键词：

IN-VITRO SELECTION; AU NANOPARTICLES; MOLECULAR NANOSTRUCTURES; GOLD NANOPARTICLES; 5-AZIDO-2'-DEOXYURIDINE 5'-TRIPHOSPHATE; MODIFIED OLIGONUCLEOTIDES; SYNTHETIC BIOLOGY; ELECTRON-TRANSFER; CRYSTAL-STRUCTURE; METAL NANOWIRES;

D O I：

10.1021/cr200104q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study was conducted to demonstrate the significance of functionalized DNA nanostructures. The unique features of DNA or of DNA/protein hybrids provided unique building blocks for the bottom-up assembly of nanoarchitectures that revealed programmed functionalities and properties, which emerged from the one-, two-, or three-dimensional ordering of the systems. These nanostructures were partially mimic cellular functionalities and served as scaffolds for the secondary templated synthesis of nanodevices. The scientific advances in the self-assembly of one-, two-, and three-dimensional ordered DNA-proteins or DNA-.nanoparticle nanostructures were also addressed in the study. The methods for the precise nanoscale spatial positioning of proteins or nanoparticles on the DNA scaffolds and the emerging properties of the programmed nanostrucutres were addressed along with their application for the templated synthesis of nanodevices.

引用

页码：2528 / 2556

页数：29

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