Prostate cancer stem cells

被引：106

作者：

Lang, S. H. ^{[1
]}

Frame, F. M. ^{[1
]}

Collins, A. T. ^{[1
]}

机构：

[1] Univ York, Dept Biol, YCR Canc Res Unit, York YO10 5DD, N Yorkshire, England

来源：

JOURNAL OF PATHOLOGY | 2009年 / 217卷 / 02期

基金：

英国惠康基金;

关键词：

prostate; stem cells; neoplasia; ANDROGEN RECEPTOR GENE; SELF-RENEWAL; EPITHELIAL-CELLS; DNA-DAMAGE; BASAL-CELL; TUMOR-SUPPRESSOR; EXPRESSION; REPAIR; CARCINOMA; RAT;

D O I：

10.1002/path.2478

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the discovery over 60 years ago by Huggins and Hodges [1] that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：299 / 306

页数：8

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