Prostate cancer stem cells

被引：106

作者：

Lang, S. H. ^{[1
]}

Frame, F. M. ^{[1
]}

Collins, A. T. ^{[1
]}

机构：

[1] Univ York, Dept Biol, YCR Canc Res Unit, York YO10 5DD, N Yorkshire, England

来源：

JOURNAL OF PATHOLOGY | 2009年 / 217卷 / 02期

基金：

英国惠康基金;

关键词：

prostate; stem cells; neoplasia; ANDROGEN RECEPTOR GENE; SELF-RENEWAL; EPITHELIAL-CELLS; DNA-DAMAGE; BASAL-CELL; TUMOR-SUPPRESSOR; EXPRESSION; REPAIR; CARCINOMA; RAT;

D O I：

10.1002/path.2478

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the discovery over 60 years ago by Huggins and Hodges [1] that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：299 / 306

页数：8

共 94 条

[61] Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells [J].

Patrawala, L ;

Calhoun, T ;

Schneider-Broussard, R ;

Li, H ;

Bhatia, B ;

Tang, S ;

Reilly, JG ;

Chandra, D ;

Zhou, J ;

Claypool, K ;

Coghlan, L ;

Tang, DG .

ONCOGENE, 2006, 25 (12) :1696-1708

[62] CD133, a novel marker for human prostatic epithelial stem cells [J].

Richardson, GD ;

Robson, CN ;

Lang, SH ;

Neal, DE ;

Maitland, NJ ;

Collins, AT .

JOURNAL OF CELL SCIENCE, 2004, 117 (16) :3539-3545

[63] Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling [J].

Roland, J ;

Murphy, BJ ;

Ahr, B ;

Robert-Hebmann, W ;

Delauzun, V ;

Nye, KE ;

Devaux, C ;

Biard-Piechaczyk, M .

BLOOD, 2003, 101 (02) :399-406

[64] Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone [J].

Roudier, MP ;

True, LD ;

Higano, CS ;

Vesselle, H ;

Ellis, W ;

Lange, P ;

Vessella, RL .

HUMAN PATHOLOGY, 2003, 34 (07) :646-653

[65] TGF-β maintains dormancy of prostatic stem cells in the proximal region of ducts [J].

Salm, SN ;

Burger, PE ;

Coetzee, S ;

Goto, K ;

Moscatelli, D ;

Wilson, EL .

JOURNAL OF CELL BIOLOGY, 2005, 170 (01) :81-90

[66] IMMUNOHISTOCHEMICAL LOCALIZATION OF THE ANDROGEN RECEPTOR IN RAT AND HUMAN TISSUES [J].

SAR, M ;

LUBAHN, DB ;

FRENCH, FS ;

WILSON, EM .

ENDOCRINOLOGY, 1990, 127 (06) :3180-3186

[67]

SETLUR SR, 2008, CANCER RES, V68, P3584

[68] DIFFERENTIAL CYTOKERATIN EXPRESSION IN NORMAL, HYPERPLASTIC AND MALIGNANT EPITHELIAL-CELLS FROM HUMAN-PROSTATE [J].

SHERWOOD, ER ;

BERG, LA ;

MITCHELL, NJ ;

MCNEAL, JE ;

KOZLOWSKI, JM ;

LEE, C .

JOURNAL OF UROLOGY, 1990, 143 (01) :167-171

[69] p63 is a prostate basal cell marker and is required for prostate development [J].

Signoretti, S ;

Waltregny, D ;

Dilks, J ;

Isaac, B ;

Lin, D ;

Garraway, L ;

Yang, A ;

Montironi, R ;

McKeon, F ;

Loda, M .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (06) :1769-1775

[70] p63 regulates commitment to the prostate cell lineage [J].

Signoretti, S ;

Pires, MM ;

Lindauer, M ;

Horner, JW ;

Grisanzio, C ;

Dhar, S ;

Majumder, P ;

McKeon, F ;

Kantoff, PW ;

Sellers, WR ;

Loda, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (32) :11355-11360

← 1 2 3 4 5 6 7 8 9 10 →