Mouse models created to study the pathophysiology of Type 2 diabetes

被引：33

作者：

LeRoith, D

Gavrilova, O

机构：

[1] Natl Inst Hlth, Diabet Branch, Bethesda, MD 20892 USA

[2] NIDDK, Mouse Metab Core Facil, NIH, Bethesda, MD 20892 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2006年 / 38卷 / 5-6期

关键词：

type; 2; diabetes; insulin resistance; mouse models; gene-deletion; transgenics;

D O I：

10.1016/j.biocel.2005.01.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity and Type 2 diabetes have become epidemics in the Western world. Understanding the pathophysiology of the disease should help in prevention and treatment of these disorders. A common theme is the presence of insulin resistance that eventually results in Type 2 diabetes. To understand the underlying mechanisms in the progression of the disease states, investigators have created mouse models by transgenic overexpression of a candidate gene or produced gene-deletion mouse models. This review will summarize many of the more appropriate models that study insulin resistance and Type 2 diabetes. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：904 / 912

页数：9

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