Asymmetric synthesis of (-)-nupharamine and (-)-(5S, 8R, 9S)-5-(3-furyl)-8-methyloctahydroindolizidine from β-amino ketones and the intramolecular Mannich reaction

被引：40

作者：

Davis, Franklin A. ^{[1
]}

Santhanaraman, Manikandan ^{[1
]}

机构：

[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 11期

关键词：

D O I：

10.1021/jo060371j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric synthesis of the 2,3,6-trisubstituted piperidine core of the antitumor Nuphar alkaloids was readily achieved by using the intramolecular Mannich reaction and a sulfinimine-derived beta-amino ketone.

引用

页码：4222 / 4226

页数：5

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