Structural correlates of pain in joints with osteoarthritis

Objective: To describe the insights on the epidemiology of pain-structure association and the ramifications of these studies for clinical trials. Design: Narrative review summarizing the pertinent literature in this area, summarizing some of the methodologic challenges inherent and proposing some research initiatives to further understanding of this complex science. Results: The predominant symptom in most patients presenting with osteoarthritis (OA) is pain. Over recent years a number of imaging based studies have narrowed the discord between structural findings on imaging and symptoms. The interpretation of pain in OA is still enigmatic and difficult to deal with both for clinicians and scientists. Conclusions: We would envisage that over the next few years many of the pressing questions pertaining to research into the structure pain relationship will continue to be addressed. With this, we can expect clinically appropriate therapeutic advance. (c) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.