Nearinfrared time-resolved spectroscopy system for tissue oxygenation monitor

被引：56

作者：

Oda, M ^{[1
]}

Yamashita, Y ^{[1
]}

Nakano, T ^{[1
]}

Suzuki, A ^{[1
]}

Shimizu, K ^{[1
]}

Hirano, I ^{[1
]}

Shimomura, F ^{[1
]}

Ohmae, E ^{[1
]}

Suzuki, T ^{[1
]}

Tsuchiya, Y ^{[1
]}

机构：

[1] Hamamatsu Photon KK, Cent Res Lab, Shizuoka 4348601, Japan

来源：

OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE III, PROCEEDINGS OF | 1999年 / 3597卷

关键词：

nearinfrared spectroscopy; time-resolved measurement; tissue; oxygenation; hemoglobin; photon counting; laser diode; photomultiplier tube; time-correlated single photon counting method;

D O I：

10.1117/12.356809

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We developed a three wavelength time-resolved spectroscopy system called the TRS-10 for use as a tissue oxygenation monitor. The TRS-10 achieved a higher data acquisition rate and a system miniaturization maintaining high sensitivity and time resolution. The TRS-10 consists of a three wavelength picosecond light pulser (PLP) with auto power control as a pulsed light source, a photomultiplier tube (PMT) having high speed and high sensitivity and miniaturized signal processing circuits for time-resolved measurement (CFD, TAG, AID converter and histogram memory). The TRS-10 system was used to measure the time course of oxygen metabolism in a human forearm with a pneumatic cuff attached to occlude blood flow. Our system succeeded in accurately measuring concentrations of Oxy- (HbO(2)) and deoxyhemoglobin (Hb) in the human forearm based on diffusion theory by means of TRS data observation having an accumulation time of one second per point.

引用

页码：611 / 617

页数：7

共 23 条

[1] THE THEORETICAL BASIS FOR THE DETERMINATION OF OPTICAL PATHLENGTHS IN TISSUE - TEMPORAL AND FREQUENCY-ANALYSIS [J].

ARRIDGE, SR ;

COPE, M ;

DELPY, DT .

PHYSICS IN MEDICINE AND BIOLOGY, 1992, 37 (07) :1531-1560

[2] COMPARISON OF TIME-RESOLVED AND TIME-UNRESOLVED MEASUREMENTS OF DEOXYHEMOGLOBIN IN BRAIN [J].

CHANCE, B ;

LEIGH, JS ;

MIYAKE, H ;

SMITH, DS ;

NIOKA, S ;

GREENFELD, R ;

FINANDER, M ;

KAUFMANN, K ;

LEVY, W ;

YOUNG, M ;

COHEN, P ;

YOSHIOKA, H ;

BORETSKY, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) :4971-4975

[3] TIME-RESOLVED SPECTROSCOPY OF HEMOGLOBIN AND MYOGLOBIN IN RESTING AND ISCHEMIC MUSCLE [J].

CHANCE, B ;

NIOKA, S ;

KENT, J ;

MCCULLY, K ;

FOUNTAIN, M ;

GREENFELD, R ;

HOLTOM, G .

ANALYTICAL BIOCHEMISTRY, 1988, 174 (02) :698-707

[4] ESTIMATION OF OPTICAL PATHLENGTH THROUGH TISSUE FROM DIRECT TIME OF FLIGHT MEASUREMENT [J].

DELPY, DT ;

COPE, M ;

VANDERZEE, P ;

ARRIDGE, S ;

WRAY, S ;

WYATT, J .

PHYSICS IN MEDICINE AND BIOLOGY, 1988, 33 (12) :1433-1442

[5] SPECTRAL DEPENDENCE OF TEMPORAL POINT SPREAD FUNCTIONS IN HUMAN TISSUES [J].

ESSENPREIS, M ;

ELWELL, CE ;

COPE, M ;

VANDERZEE, P ;

ARRIDGE, SR ;

DELPY, DT .

APPLIED OPTICS, 1993, 32 (04) :418-425

[6] TIME-RESOLVED SPECTROSCOPY OF THE HUMAN FOREARM [J].

FERRARI, M ;

WEI, QN ;

CARRARESI, L ;

DEBLASI, RA ;

ZACCANTI, G .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1992, 16 (02) :141-153

[7] SCALING RELATIONSHIPS FOR THEORIES OF ANISOTROPIC RANDOM-WALKS APPLIED TO TISSUE OPTICS [J].

GANDJBAKHCHE, AH ;

NOSSAL, R ;

BONNER, RF .

APPLIED OPTICS, 1993, 32 (04) :504-516

[8] CHARACTERIZATION OF ABSORPTION AND SCATTERING PROPERTIES OF SMALL-VOLUME BIOLOGICAL SAMPLES USING TIME-RESOLVED SPECTROSCOPY [J].

LIU, H ;

MIWA, M ;

BEAUVOIT, B ;

WANG, NG ;

CHANCE, B .

ANALYTICAL BIOCHEMISTRY, 1993, 213 (02) :378-385

[9] EXPERIMENTAL TESTS OF A SIMPLE DIFFUSION-MODEL FOR THE ESTIMATION OF SCATTERING AND ABSORPTION-COEFFICIENTS OF TURBID MEDIA FROM TIME-RESOLVED DIFFUSE REFLECTANCE MEASUREMENTS [J].

MADSEN, SJ ;

WILSON, BC ;

PATTERSON, MS ;

PARK, YD ;

JACQUES, SL ;

HEFETZ, Y .

APPLIED OPTICS, 1992, 31 (18) :3509-3517

[10]

Miwa M, 1995, P SOC PHOTO-OPT INS, V2389, P142

← 1 2 3 →