Manufacturing of human placenta-derived mesenchymal stem cells for clinical trials

被引：104

作者：

Brooke, Gary

Rossetti, Tony

Pelekanos, Rebecca

Ilic, Nina ^{[4
]}

Murray, Patricia

Hancock, Sonia

Antonenas, Vicki ^{[2
]}

Huang, Gillian ^{[2
]}

Gottlieb, David ^{[2
]}

Bradstock, Ken ^{[2
]}

Atkinson, Kerry ^{[1
,3
]}

机构：

[1] Mater Med Res Inst, Biotherapy Program, Adult Stem Cell Lab, Brisbane, Qld 4101, Australia

[2] Westmead Hosp, Dept Haematol & Bone Marrow Transplantat, Sydney, NSW, Australia

[3] Univ Queensland, Brisbane, Qld, Australia

[4] Mater Adult Hosp, Mater Hlth Serv, Brisbane, Qld, Australia

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2009年 / 144卷 / 04期

关键词：

mesenchymal stem cell; human; cell therapy; good manufacturing practice production; clinical trial; HUMAN BONE-MARROW; STROMAL CELLS; HEART FUNCTION; FETAL;

D O I：

10.1111/j.1365-2141.2008.07492.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mesenchymal stem cells (MSC) are being used increasingly in clinical trials for a range of regenerative and inflammatory diseases. Bone marrow is the traditional source but is relatively inaccessible in large volume. MSC have now been derived from tissues other than bone marrow including placenta and adipose tissue. We have used placenta obtained after delivery as a source of MSC and have been unable to detect any marked differences from marrow-derived MSC in terms of cell surface phenotype, chemokine receptor display, mesodermal differentiation capacity or immunosuppressive ability. This report described our manufacturing process for isolating and expanding placenta-derived human MSC and their safe infusion into the first patient in a clinical trial program of human placenta-derived MSC.

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收藏

页码：571 / 579

页数：9

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