Click chemistry: A powerful tool to create polymer-based macromolecular chimeras

被引：143

作者：

Le Droumaguet, Benjamin ^{[2
]}

Velonia, Kelly ^{[1
]}

机构：

[1] Univ Crete, Dept Mat Sci & Technol, Iraklion 71305, Crete, Greece

[2] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2008年 / 29卷 / 12-13期

关键词：

D O I：

10.1002/marc.200800155

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The combination of polymeric with biological materials, to create biohybrid macromolecules that merge the properties of both the natural and synthetic components, is a flourishing area in both life sciences and biotechnology. The click chemistry philosophy has recently provided a powerful tool in this direction, leading to a plethora of novel, tailor-made biomacromolecules with unprecedented structural characteristics and properties. The different synthetic strategies, using the alkyne-azide click cycloadditions to bioorthogonally achieve the coupling of synthetic polymers with nucleic acids, peptides, sugars, proteins or even viruses and cells is described. The review covers the latest developments in this very dynamic and rapidly expanding field.

引用

页码：1073 / 1089

页数：17

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