Ring closure to β-turn mimics via copper-catalyzed azide/alkyne cycloadditions

被引：122

作者：

Angell, Y ^{[1
]}

Burgess, K ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 23期

关键词：

D O I：

10.1021/jo0516180

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed azide alkyne cycloadditions of the linear substrates 1 were used to form the cyclic derivatives 2. Computational, NMR, and CD analyses of these compounds indicate that their most favorable conformational states include type I and type H beta-turn conformations. Selectivity for the dimeric products 6 in these cyclization reactions is discussed.

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页码：9595 / 9598

页数：4

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