共 51 条
A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome
被引:206
作者:

Alekseyenko, Artyom A.
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机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Peng, Shouyong
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机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Childrens Hosp, Childrens Hosp Informat Program, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Larschan, Erica
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机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Gorchakov, Andrey A.
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Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Lee, Ok-Kyung
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机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Kharchenko, Peter
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Childrens Hosp, Childrens Hosp Informat Program, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

McGrath, Sean D.
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机构:
Washington Univ, Sch Med, Dept Genet, St Louis, MO 63108 USA
Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Wang, Charlotte I.
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Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Mardis, Elaine R.
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机构:
Washington Univ, Sch Med, Dept Genet, St Louis, MO 63108 USA
Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Park, Peter J.
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h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Childrens Hosp, Childrens Hosp Informat Program, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA

Kuroda, Mitzi I.
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h-index: 0
机构:
Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
机构:
[1] Brigham & Womens Hosp, Dept Med, Div Genet, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[3] Childrens Hosp, Childrens Hosp Informat Program, Boston, MA 02115 USA
[4] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63108 USA
[5] Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
来源:
基金:
美国国家卫生研究院;
关键词:
D O I:
10.1016/j.cell.2008.06.033
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The Drosophila MSL complex associates with active genes specifically on the male X chromosome to acetylate histone H4 at lysine 16 and increase expression approximately 2-fold. To date, no DNA sequence has been discovered to explain the specificity of MSL binding. We hypothesized that sequence-specific targeting occurs at "chromatin entry sites,'' but the majority of sites are sequence independent. Here we characterize 150 potential entry sites by ChIP-chip and ChIP-seq and discover a GA-rich MSL recognition element (MRE). The motif is only slightly enriched on the X chromosome (similar to 2fold), but this is doubled when considering its preferential location within or 30 to active genes (> 4-fold enrichment). When inserted on an autosome, a newly identified site can direct local MSL spreading to flanking active genes. These results provide strong evidence for both sequence-dependent and -independent steps in MSL targeting of dosage compensation to the male X chromosome.
引用
收藏
页码:599 / 609
页数:11
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