Beyond comparison - antibiotics from genome data?

被引：5

作者：

Alekshun, MN ^{[1
]}

机构：

[1] Paratek Pharmaceut, Boston, MA 02111 USA

来源：

NATURE BIOTECHNOLOGY | 2001年 / 19卷 / 12期

关键词：

D O I：

10.1038/nbt1201-1124

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

12

引用

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页码：1124 / 1125

页数：2

相关论文

共 11 条

[1]

Bacterial virulence as a target for antimicrobial chemotherapy [J].

Alksne, LE ;

Projan, SJ .

CURRENT OPINION IN BIOTECHNOLOGY, 2000, 11 (06) :625-636

[2]

Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori [J].

Alm, RA ;

Ling, LSL ;

Moir, DT ;

King, BL ;

Brown, ED ;

Doig, PC ;

Smith, DR ;

Noonan, B ;

Guild, BC ;

deJonge, BL ;

Carmel, G ;

Tummino, PJ ;

Caruso, A ;

Uria-Nickelsen, M ;

Mills, DM ;

Ives, C ;

Gibson, R ;

Merberg, D ;

Mills, SD ;

Jiang, Q ;

Taylor, DE ;

Vovis, GF ;

Trost, TJ .

NATURE, 1999, 397 (6715) :176-180

[3]

Glaser P, 2001, SCIENCE, V294, P849

[4]

Hayashi T, 2001, DNA RES, V8, P11, DOI 10.1093/dnares/8.1.11

[5]

Black holes and bacterial pathogenicity:: A large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli [J].

Maurelli, AT ;

Fernández, RE ;

Bloch, CA ;

Rode, CK ;

Fasano, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3943-3948

[6]

Complete genome sequence of Salmonella enterica serovar typhimurium LT2 [J].

McClelland, M ;

Sanderson, KE ;

Spieth, J ;

Clifton, SW ;

Latreille, P ;

Courtney, L ;

Porwollik, S ;

Ali, J ;

Dante, M ;

Du, FY ;

Hou, SF ;

Layman, D ;

Leonard, S ;

Nguyen, C ;

Scott, K ;

Holmes, A ;

Grewal, N ;

Mulvaney, E ;

Ryan, E ;

Sun, H ;

Florea, L ;

Miller, W ;

Stoneking, T ;

Nhan, M ;

Waterston, R ;

Wilson, RK .

NATURE, 2001, 413 (6858) :852-856

[7]

Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18 [J].

Parkhill, J ;

Dougan, G ;

James, KD ;

Thomson, NR ;

Pickard, D ;

Wain, J ;

Churcher, C ;

Mungall, KL ;

Bentley, SD ;

Holden, MTG ;

Sebaihia, M ;

Baker, S ;

Basham, D ;

Brooks, K ;

Chillingworth, T ;

Connerton, P ;

Cronin, A ;

Davis, P ;

Davies, RM ;

Dowd, L ;

White, N ;

Farrar, J ;

Feltwell, T ;

Hamlin, N ;

Haque, A ;

Hien, TT ;

Holroyd, S ;

Jagels, K ;

Krogh, A ;

Larsen, TS ;

Leather, S ;

Moule, S ;

O'Gaora, P ;

Parry, C ;

Quail, M ;

Rutherford, K ;

Simmonds, M ;

Skelton, J ;

Stevens, K ;

Whitehead, S ;

Barrell, BG .

NATURE, 2001, 413 (6858) :848-852

[8]

Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing [J].

Pizza, M ;

Scarlato, V ;

Masignani, V ;

Giuliani, MM ;

Aricò, B ;

Comanducci, M ;

Jennings, GT ;

Baldi, L ;

Bartolini, E ;

Capecchi, B ;

Galeotti, CL ;

Luzzi, E ;

Manetti, R ;

Marchetti, E ;

Mora, M ;

Nuti, S ;

Ratti, G ;

Santini, L ;

Savino, S ;

Scarselli, M ;

Storni, E ;

Zuo, PJ ;

Broeker, M ;

Hundt, E ;

Knapp, B ;

Blair, E ;

Mason, T ;

Tettelin, H ;

Hood, DW ;

Jeffries, AC ;

Saunders, NJ ;

Granoff, DM ;

Venter, JC ;

Moxon, ER ;

Grandi, G ;

Rappuoli, R .

SCIENCE, 2000, 287 (5459) :1816-1820

[9]

Finding drug targets in microbial genomes [J].

Read, TD ;

Gill, SR ;

Tettelin, H ;

Dougherty, BA .

DRUG DISCOVERY TODAY, 2001, 6 (17) :887-892

[10]

Strohl W.R., 1997, Biotechnology of antibiotics