The SLC6/NSS family members KAAT1 and CAATCH1 have weak chloride dependence

被引：7

作者：

Bette, Sara ^{[1
]}

Castagna, Michela ^{[1
]}

Bossi, Elena ^{[2
,3
]}

Peres, Antonio ^{[2
,3
]}

Sacchi, Vellea Franca ^{[1
]}

机构：

[1] Univ Milan, Sch Pharm, Inst Gen Physiol & Biol Chem G Esposilo, I-20134 Milan, Italy

[2] Univ Insubria, Dept Biotechnol & Mol Sci, Varese, Italy

[3] Univ Insubria, Ctr Neurosci, Varese, Italy

来源：

CHANNELS | 2008年 / 2卷 / 05期

关键词：

chloride-dependence; KAAT1; CAATCH1; amino acid transport; structure/function;

D O I：

10.4161/chan.2.5.6901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

KAAT1 and CAATCH1 are amino acid transporters cloned from the intestine of the lepidoptera Manduca sexta.(1,2) They are members of the SLC6/NSS family, which groups membrane proteins that use Na+, K+ and Cl- gradients for the coupled transport of amines and amino acids. The report of the atomic-resolution x-ray crystal structure of the eubacterium Aquifex aeolicus leucine transporter (AaLeuT)(3) has contributed significantly to understanding of the structure-function relationship in NSS proteins. Transport by AaLeuT is Cl- independent, whereas many neurotransmitter: sodium symporters like serotonin transporter (SERT), GABA transporter (GAT1), dopamine transporter and norephinephrine transporter, among others, are strongly Cl- dependent.(4)

引用

页码：358 / 362

页数：5

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