Integrins in prostate cancer progression

被引：139

作者：

Goel, Hira Lal

Li, Jing

Kogan, Sophia

Languino, Lucia R. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA 01605 USA

来源：

ENDOCRINE-RELATED CANCER | 2008年 / 15卷 / 03期

关键词：

D O I：

10.1677/ERC-08-0019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets. Endocrine-Related Cancer (2008) 15 657-664

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收藏

页码：657 / 664

页数：8

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