The integrin - Growth factor receptor duet

被引：133

作者：

Alam, Naved

Goel, Hira Lal

Zarif, Matthew J.

Butterfield, Julie E.

Perkins, Hillary M.

Sansoucy, Brian G.

Sawyer, Thomas K.

Languino, Lucia R. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Ctr Canc, Worcester, MA USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2007年 / 213卷 / 03期

关键词：

D O I：

10.1002/jcp.21278

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In this article, we review the role of integrins as molecular switches that modulate GFR activation and specificity. We also examine the reciprocal modulation of integrin functions by GFRs and the mechanisms through which those actions are fine-tuned.

引用

收藏

页码：649 / 653

页数：5

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