mRNA Localization: Gene Expression in the Spatial Dimension

被引：768

作者：

Martin, Kelsey C. ^{[1
]}

Ephrussi, Anne ^{[2
]}

机构：

[1] Univ Calif Los Angeles, Dept Biol Chem, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[2] European Mol Biol Lab, Dev Biol Unit, D-69117 Heidelberg, Germany

来源：

CELL | 2009年 / 136卷 / 04期

关键词：

FRAGILE-X-SYNDROME; XENOPUS-OOCYTES; ENDOPLASMIC-RETICULUM; SYNAPTIC PLASTICITY; HIPPOCAMPAL-NEURONS; RIBONUCLEOPROTEIN-PARTICLES; INTRACELLULAR-LOCALIZATION; CYTOPLASMIC LOCALIZATION; ASYMMETRIC LOCALIZATION; DROSOPHILA OOGENESIS;

D O I：

10.1016/j.cell.2009.01.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control. Recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell.

引用

收藏

页码：719 / 730

页数：12

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