Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry)

被引：76

作者：

Tomosaka, Hideyuki ^{[1
]}

Chin, Young-Won ^{[1
]}

Salim, Angela A. ^{[1
]}

Keller, William J. ^{[2
]}

Chai, Heebyung ^{[1
]}

Kinghorn, A. Douglas ^{[1
]}

机构：

[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[2] Nat Sunshine Prod Inc, Spanish Fork, UT 84660 USA

来源：

PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 07期

关键词：

Berberis vulgaris; barberry; Berberidaceae; botanical dietary supplements; antioxidant activity; cytoprotective activity; cannabisin G; (+/-)-lyoniresinol;

D O I：

10.1002/ptr.2443

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Activity-guided fractionation of an EtOAc-soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical-scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N-(p-trans-conmaroyl)tyramine, cannabisin G and (+/-)-lyoniresinol. Of these, cannabisin G and (+/-)-lyoniresinol exhibited antioxidant activity in this bioassay. Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF-7 cells modulated by hydrogen peroxide. Copyright (c) 2008 John Wiley & Sons, Ltd.

引用

页码：979 / 981

页数：3

共 18 条

[1]

Arayne MS, 2007, PAK J PHARM SCI, V20, P83

[2] Cytoprotection by Achyrocline satureioides (Lam) DC and some of its main flavonoids against oxidative stress [J].

Arredondo, MF ;

Blasina, F ;

Echeverry, C ;

Morquio, A ;

Ferreira, M ;

Abin-Carriquiry, JA ;

Lafon, L ;

Dajas, F .

JOURNAL OF ETHNOPHARMACOLOGY, 2004, 91 (01) :13-20

[3] Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra) [J].

Chin, Young-Won ;

Jung, Hyun-Ah ;

Liu, Yue ;

Su, Bao-Ning ;

Castoro, John A. ;

Keller, William J. ;

Pereira, Michael A. ;

Kinghorn, A. Douglas .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (12) :4691-4697

[4]

CHIN YW, 2008, PHYTOCHEMIS IN PRESS

[5]

Elkhateeb A, 2007, NAT PROD COMMUN, V2, P173

[6] A pharmacological study on Berberis vulgaris fruit extract [J].

Fatehi, M ;

Saleh, TM ;

Fatehi-Hassanabad, Z ;

Farrokhfal, K ;

Jafarzadeh, M ;

Davodi, S .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 102 (01) :46-52

[7] The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive rats [J].

Fatehi-Hassanabad, Z ;

Jafarzadeh, M ;

Tarhini, A ;

Fatehi, M .

PHYTOTHERAPY RESEARCH, 2005, 19 (03) :222-225

[8] Dietary antioxidants in disease prevention [J].

Gordon, MH .

NATURAL PRODUCT REPORTS, 1996, 13 (04) :265-273

[9] Heartwood constituents of Betula maximowicziana [J].

Hanawa, F ;

Shiro, M ;

Hayashi, Y .

PHYTOCHEMISTRY, 1997, 45 (03) :589-595

[10] Antioxidant xanthones from the pericarp of Garcinia mangostana (mangosteen) [J].

Jung, HA ;

Su, BN ;

Keller, WJ ;

Mehta, RG ;

Kinghorn, AD .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (06) :2077-2082

← 1 2 →