Selection of Streptococcus pneumoniae mutants having reduced susceptibility to moxifloxacin and levofloxacin

被引：78

作者：

Li, XY ^{[1
]}

Zhao, XL ^{[1
]}

Drlica, K ^{[1
]}

机构：

[1] Publ Hlth Res Inst, New York, NY 10016 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 02期

关键词：

D O I：

10.1128/AAC.46.2.522-524.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

With Streptococcus pneumoniae, moxifloxacin was 4- and 10-fold more effective than levofloxacin at restricting selection of resistant mutants and at killing resistant mutants, respectively. The selection frequency for first-step topoisomerase mutants was 1,000 times lower for moxifloxacin than for levofloxacin; this difference was lost when second-step mutants were selected.

引用

页码：522 / 524

页数：3

共 23 条

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