Mild organocatalytic α-methylenation of aldehydes

被引：115

作者：

Erkkilä, A ^{[1
]}

Pihko, PM ^{[1
]}

机构：

[1] Aalto Univ, Organ Chem Lab, FI-02015 Helsinki, Finland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 06期

关键词：

D O I：

10.1021/jo052529q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A rapid and extremely convenient method for alpha-methylenation of aldehydes with aqueous formaldehyde is described. Two optimal catalytic systems are presented that allow short reaction times and afford the functionalized products in good to excellent yields (up to 99%) and chemoselectivity.

引用

页码：2538 / 2541

页数：4

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