Blazeispirols B, C, E and F, des-A-ergostane-type compounds from the cultured mycelia of the fungus Agaricus blazei

被引：29

作者：

Hirotani, M ^{[1
]}

Sai, K ^{[1
]}

Hirotani, S ^{[1
]}

Yoshikawa, T ^{[1
]}

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan

来源：

PHYTOCHEMISTRY | 2002年 / 59卷 / 05期

关键词：

Agaricus blazei; Agaricaceae; Basidiomycetes; higher fungi; des-A-steroid; blazeispirols A; B; C; D; E and F;

D O I：

10.1016/S0031-9422(01)00445-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Four new des-A-ergostane derivatives including blazeispirols B, C, E and F were isolated from the cultured mycelia of fungus Agaricus blazei Murill and were established to be (20S, 22R, 23R, 24S)-14beta,22: 22,25-diepoxy-5-methoxy-des-A-ergosta-5.7,9.11-tetraen-23-ol; (20S, 22S, 23R, 24S)-14beta,22: 22.25-diepoxy-5-methoxy-des-A-ergosta-5,7,9-trien-23-ol, (20S, 22S, 23R, 24s)-14beta, 22: 22, 25-diepoxy-5-methoxy-des-A-ergosta-5,7,9,11-tetraene-19,23-diol and (20S., 22S, 23R. 24S)-14beta,22: 22,25-diepoxy-des-A-ergosta-5,7,9-triene-5,23-diol by comparison of extensive 1D and 2D NMR spectral data with that of blazeispirol A. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：571 / 577

页数：7

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