A role for neuromedin U in stress response

被引：106

作者：

Hanada, R

Nakazato, M ^{[1
]}

Murakami, N

Sakihara, S

Yoshimatsu, H

Toshinai, K

Hanada, T

Suda, T

Kangawa, K

Matsukura, S

Sakata, T

机构：

[1] Miyazaki Med Coll, Dept Internal Med, Miyazaki 8891692, Japan

[2] Oita Med Univ, Dept Internal Med 1, Oita 8795593, Japan

[3] Miyazaki Univ, Fac Agr, Dept Vet Physiol, Miyazaki 8892192, Japan

[4] Hirosaki Univ, Sch Med, Dept Internal Med 3, Hirosaki, Aomori 0368562, Japan

[5] Suntory Inst Med Res & Dev, Gunma 3700503, Japan

[6] Natl Cardiovasc Ctr, Res Inst, Dept Biochem, Suita, Osaka 5658565, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 289卷 / 01期

关键词：

neuromedin U; hypothalamus; CRH; stress; CRH KO mice;

D O I：

10.1006/bbrc.2001.5945

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuromedin U (NMU) is a hypothalamic peptide that has been recently found to reduce food intake, but few is known about its other functions in the central nervous system. We here studied behavioral activities induced by an intracerebroventricular (ICV) administration of NMU in rats and mice. NMU increased gross locomotor activity, face washing behavior, and grooming. NMU-induced stress response was significantly abolished by pretreatment with an antagonist of corticotropin-releasing hormone (CRH), alpha -helical CRH (9-41) (alpha -hCRH), or anti-CRH IgG. NMU did not induce locomotor activity in CRH knockout mice. NMU that interacts anatomically and/or functionally with the CRH system is a novel physiological regulator of stress response. (C) 2001 Academic Press.

引用

页码：225 / 228

页数：4

共 20 条

[1] INTRAVENTRICULAR CORTICOTROPIN-RELEASING FACTOR ENHANCES BEHAVIORAL-EFFECTS OF NOVELTY [J].