WNT signaling in malignant mesothelioma

被引：19

作者：

Fox, Simon

Dharmarajan, Arun ^{[1
]}

机构：

[1] Univ Western Australia, Sch Anat & Human Biol, Nedlands, WA 6009, Australia

[2] Curtin Univ Technol, Sch Pharm, Pharmacogenet Lab, Bentley, WA 6102, Australia

[3] W Australian Biomed Res Inst, Bentley, WA, Australia

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2006年 / 11卷

关键词：

mesothelioma; Wnt; frizzled; sFRP; apoptosis; review;

D O I：

10.2741/1953

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neoplastic transformation of mesothelium is commonly associated with exposure to asbestos and gives rise to malignant mesothelioma, an aggressive disease that has proved particularly refractory to conventional anticancer therapies. The Wnt signaling pathways play key roles in fundamental processes, which include both development and homeostasis. The importance of these pathways in tumorigenesis is emphasized by the many cancers which show aberrations in Wnt signaling. In this review we examine the current evidence for activation of Wnt signaling and the abnormal expression of specific molecules in malignant mesothelioma.

引用

收藏

页码：2106 / 2112

页数：7

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