Protein kinase D: an intracellular traffic regulator on the move

被引：184

作者：

Van Lint, J

Rykx, A

Maeda, Y

Vantus, T

Sturany, S

Malhotra, V

Vandenheede, JR

Seufferlein, T

机构：

[1] Katholieke Univ Leuven, Fac Med, Div Biochem, B-3000 Louvain, Belgium

[2] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[3] Univ Ulm, Fac Med, Div Internal Med, D-09081 Ulm, Germany

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(02)02262-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent research has identified protein kinase D (PKD, also called PKCmu) as a serine/threonine kinase with potentially important roles in growth factor signaling as well as in stress-induced signaling. Moreover, PKD has emerged as an important regulator of plasma membrane enzymes and receptors, in some cases mediating cross-talk between different signaling systems. The recent discovery of two additional kinases belonging to the PKD family and the plethora of proteins that interact with PKD point to a multifaceted regulation and a multifunctional role for these enzymes, with functions in processes as diverse as cell proliferation, apoptosis, immune cell regulation, tumor cell invasion and regulation of Golgi vesicle fission.

引用

收藏

页码：193 / 200

页数：8

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