Aminoglycoside microarrays to study antibiotic resistance

被引：44

作者：

Disney, MD

Magnet, S

Blanchard, JS

Seeberger, PH

机构：

[1] ETH Honggerberg HCI F3135, Swiss Fed Inst Technol, Organ Chem Lab, CH-8093 Zurich, Switzerland

[2] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 12期

关键词：

antibiotics; bioorganic chemistry; carbohydrates; combinatorial chemistry; high-throughput screening;

D O I：

10.1002/anie.200353236

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On to the next round! A sensitive microarray of immobilized aminoglycosides was used to study the binding of antibiotics to resistance-causing enzymes (see picture). This, in combination with other methods, will lead to the identification of new antibiotics that bind weakly to these enzymes and strongly to the therapeutic targets.

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收藏

页码：1591 / 1594

页数：4

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