Aminoglycoside microarrays to study antibiotic resistance

被引：44

作者：

Disney, MD

Magnet, S

Blanchard, JS

Seeberger, PH

机构：

[1] ETH Honggerberg HCI F3135, Swiss Fed Inst Technol, Organ Chem Lab, CH-8093 Zurich, Switzerland

[2] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 12期

关键词：

antibiotics; bioorganic chemistry; carbohydrates; combinatorial chemistry; high-throughput screening;

D O I：

10.1002/anie.200353236

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On to the next round! A sensitive microarray of immobilized aminoglycosides was used to study the binding of antibiotics to resistance-causing enzymes (see picture). This, in combination with other methods, will lead to the identification of new antibiotics that bind weakly to these enzymes and strongly to the therapeutic targets.

引用

页码：1591 / 1594

页数：4

共 15 条

[11] Printing small molecules as microarrays and detecting protein-ligand interactions en masse [J].