Role of glutamate receptor subtypes in the lamprey respiratory network

被引:28
作者
Bongianni, F
Deliagina, TG
Grillner, S
机构
[1] Univ Florence, Dipartimento Sci Fisiol, I-50134 Florence, Italy
[2] Karolinska Inst, Nobel Inst Neurophysiol, Dept Neurosci, S-17177 Stockholm, Sweden
关键词
respiration; excitatory amino acid; ionotropic glutamate receptor; metabotropic glutamate receptor; lamprey; control of breathing;
D O I
10.1016/S0006-8993(99)01251-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The respiratory role of glutamate receptors was investigated in the isolated lamprey brain preparation by analyzing the changes in respiratory activity induced by bath application of specific antagonists of ionotropic and metabotropic glutamate receptors. The results show that these antagonists differentially affect the pattern of breathing and provide the first evidence that both ionotropic and metabotropic glutamate receptors are involved in neurotransmission within the lamprey respiratory network. (C) 1999 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:298 / 302
页数:5
相关论文
共 19 条
[1]   CENTRAL CONTROL OF BREATHING IN MAMMALS - NEURONAL CIRCUITRY, MEMBRANE-PROPERTIES, AND NEUROTRANSMITTERS [J].
BIANCHI, AL ;
DENAVITSAUBIE, M ;
CHAMPAGNAT, J .
PHYSIOLOGICAL REVIEWS, 1995, 75 (01) :1-45
[2]   EFFECTS OF MAGNESIUM ON FICTIVE LOCOMOTION INDUCED BY ACTIVATION OF N-METHYL-D-ASPARTATE (NMDA) RECEPTORS IN THE LAMPREY SPINAL-CORD INVITRO [J].
BRODIN, L ;
GRILLNER, S .
BRAIN RESEARCH, 1986, 380 (02) :244-252
[3]   Pharmacology and functions of metabotropic glutamate receptors [J].
Conn, PJ ;
Pin, JP .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 :205-237
[4]  
Dong XW, 1996, J NEUROSCI, V16, P4971
[5]   ROLE OF EXCITATORY AMINO-ACIDS IN THE GENERATION AND TRANSMISSION OF RESPIRATORY DRIVE IN NEONATAL RAT [J].
GREER, JJ ;
SMITH, JC ;
FELDMAN, JL .
JOURNAL OF PHYSIOLOGY-LONDON, 1991, 437 :727-749
[6]   7-CHLOROKYNURENIC ACID BLOCKS NMDA RECEPTOR-INDUCED FICTIVE LOCOMOTION IN LAMPREY EVIDENCE FOR A PHYSIOLOGICAL-ROLE OF THE GLYCINE SITE [J].
GRILLNER, P ;
HILL, R ;
GRILLNER, S .
ACTA PHYSIOLOGICA SCANDINAVICA, 1991, 141 (01) :131-132
[7]   NEURAL NETWORKS THAT COORDINATE LOCOMOTION AND BODY ORIENTATION IN LAMPREY [J].
GRILLNER, S ;
DELIAGINA, T ;
EKEBERG, O ;
ELMANIRA, A ;
HILL, RH ;
LANSNER, A ;
ORLOVSKY, GN ;
WALLEN, P .
TRENDS IN NEUROSCIENCES, 1995, 18 (06) :270-279
[9]   EFFECTS OF METABOTROPIC GLUTAMATE-RECEPTOR ACTIVATION ON THE CELLULAR AND NETWORK LEVEL IN THE LAMPREY SPINAL-CORD [J].
KRIEGER, P ;
TEGNER, J ;
ELMANIRA, A ;
GRILLNER, S .
NEUROREPORT, 1994, 5 (14) :1760-1762
[10]   Activation of pharmacologically distinct metabotropic glutamate receptors depresses reticulospinal-evoked monosynaptic EPSPs in the lamprey spinal cord [J].
Krieger, P ;
ElManira, A ;
Grillner, S .
JOURNAL OF NEUROPHYSIOLOGY, 1996, 76 (06) :3834-3841