Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2′-deoxyinosine:: A new chemoenzymatic synthesis of the antiviral drug 2′,3′-dideoxyinosine

被引：24

作者：

Ciuffreda, P ^{[1
]}

Casati, S ^{[1
]}

Santaniello, E ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Preclin LITA Vialba, I-20157 Milan, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(99)00228-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarctica and Pseudomonas sp. lipases in organic solvents; starting from the 5'-acetyl derivative of 2'-deoxyinosine, compound 5a, an efficient chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine 1c has been achieved, (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1577 / 1582

页数：6

共 12 条

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